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Abnova
TNFRSF1B Polyclonal Antibody, MaxPab™
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TNFRSF1B Antibody (H00007133-D01P) in WB
Western Blot analysis of TNFRSF1B expression in transfected 293T cell line (H00007133-T01) by TNFRSF1B MaxPab polyclonal antibody.
Lane 1: TNFRSF1B transfected lysate(48.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: TNFRSF1B transfected lysate(48.30 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00007133-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TNFRSF1B (NP_001057.1, 1 a.a. approximately 461 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S
靶标信息
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD120b; p75; p75 TNF receptor; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II
基因别名: CD120b; p75; p75TNFR; TBPII; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr-2; TNFR1B; TNFR2; TNFR80; TNFRII; TNFRSF1B
UniProt ID: (Human) P20333, (Mouse) P25119
Entrez Gene ID: (Human) 7133, (Mouse) 21938
inflammatory response
immune response
multicellular organism development
aging
intrinsic apoptotic signaling pathway in response to DNA damage
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of inflammatory response
RNA destabilization
positive regulation of membrane protein ectodomain proteolysis
cellular response to lipopolysaccharide
cellular response to growth factor stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
cell surface receptor signaling pathway
cell proliferation
programmed cell death
