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Invitrogen
TOP2A Recombinant Rabbit Monoclonal Antibody (5B10)
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TOP2A Antibody (MA5-38371) in IHC (P)
Immunohistochemistry (Paraffin) analysis of TOP2A in paraffin-embedded human lung cancer using TOP2A Monoclonal Antibody (Product # MA5-38371) diluted at 1:100. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is det... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-38371
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5B10
抗原
A synthesized peptide derived from human Topoisomerase II alpha
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
规格
25 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody has been tested in direct-ELISA
靶标信息
Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA topoisomerase 2-alpha; DNA Topoisomerase II alpha; DNA topoisomerase II, alpha isozyme; EC 5.99.1.3; OTTHUMP00000207108; P11388-1; topoisomerase ii alpha
基因别名: Top-2; TOP2; TOP2A
UniProt ID: (Mouse) Q01320
Entrez Gene ID: (Mouse) 21973
nucleotide binding
magnesium ion binding
DNA binding
chromatin binding
DNA topoisomerase activity
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
drug binding
DNA binding, bending
isomerase activity
enzyme binding
protein homodimerization activity
histone deacetylase binding
ubiquitin binding
sequence-specific DNA binding
structure-specific DNA binding
poly(A) RNA binding
metal ion binding
protein heterodimerization activity
DNA metabolism protein
resolution of meiotic recombination intermediates
sister chromatid segregation
hematopoietic progenitor cell differentiation
DNA metabolic process
DNA topological change
DNA ligation
DNA unwinding involved in DNA replication
cellular response to DNA damage stimulus
chromosome segregation
chromosome condensation
apoptotic chromosome condensation
embryonic cleavage
regulation of circadian rhythm
positive regulation of apoptotic process
mitotic DNA integrity checkpoint
positive regulation of viral genome replication
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
