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Invitrogen
TOPBP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106268
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TOPBP1(Accession Q92547), corresponding to amino acid residues V1133-S1183.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total TOPBP1.
靶标信息
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; KIAA0259; TOPBP 1; TopBP1; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1; unnamed protein product
基因别名: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; Dpb11; KIAA0259; mKIAA0259; TOP2BP1; TOPBP1
UniProt ID: (Human) Q92547, (Mouse) Q6ZQF0
Entrez Gene ID: (Human) 11073, (Mouse) 235559
DNA replication checkpoint
DNA damage checkpoint
double-strand break repair via homologous recombination
DNA metabolic process
DNA replication initiation
DNA repair
double-strand break repair
chromatin organization
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
response to ionizing radiation
mitotic DNA replication checkpoint
reciprocal DNA recombination
chromosome organization
double-strand break repair via classical nonhomologous end joining
double-strand break repair via alternative nonhomologous end joining
broken chromosome clustering
protein localization to site of double-strand break
reciprocal meiotic recombination
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
