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Predicted to react with Mouse samples.
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase Topors; p53-binding protein 3; p53BP3; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; topoisomerase 1-binding RING finger; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Tumor suppressor p53-binding protein 3
基因别名: AW105885; LUN; P53BP3; p53BP3/LUN; RP31; TOPORS; TP53BPL
UniProt ID: (Human) Q9NS56, (Mouse) Q80Z37
Entrez Gene ID: (Human) 10210, (Mouse) 106021
分子生物学功能: ubiquitin-protein ligase