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Invitrogen
TOPORS Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-67821
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human TOPORS.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase Topors; p53-binding protein 3; p53BP3; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; topoisomerase 1-binding RING finger; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Tumor suppressor p53-binding protein 3
Gene Aliases: AW105885; LUN; P53BP3; p53BP3/LUN; RP31; TOPORS; TP53BPL
UniProt ID: (Human) Q9NS56, (Mouse) Q80Z37
Entrez Gene ID: (Human) 10210, (Mouse) 106021
DNA binding
antigen binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
DNA topoisomerase binding
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein polyubiquitination
transcription, DNA-templated
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
retina layer formation
protein sumoylation
protein localization to nucleus
photoreceptor cell outer segment organization
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
maintenance of protein location in nucleus
protein K48-linked ubiquitination
positive regulation of ubiquitin-protein transferase activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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