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Agrisera
TOR/Target of rapamycin Polyclonal Antibody
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TOR/Target of rapamycin Antibody (AS12-2608) in WB
25 mg total protein extract (35 S: Raptor-Prot G) was incubated with Ig G magnetic beads for 50 minutes. After washing, complexes were eluted, concentrated by speedvac and pellet was dissolved in 30 u L 1 x sample buffer. For SDS-PAGE 10 u L of the eluate was loaded on gel. 20,40, and 60 µg total protein extract from Arabidopsis thaliana cell suspension culture (Landsberg erecta), or At TOR protein enriched... View More
产品信息
AS12-2608
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana TOR protein sequence.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Zea mays
靶标信息
TOR genes encode large, conserved phosphatidylinositol 3-kinase-related serine/threonine protein kinases that localize predominantly to endomembrane surfaces, with TOR1 found on organelle-bounding membranes including the vacuolar membrane and also reported in the nucleus and at the plasma membrane, while TOR2 localizes to the vacuolar and plasma membranes; both act as catalytic subunits within multiprotein TOR complexes. Structurally, Tor proteins are approximately 280 kDa and are organized with extensive N-terminal HEAT repeat-rich regions that support scaffolding and complex assembly, followed by a central FAT region and an FKBP12-rapamycin-binding (FRB) module that mediates rapamycin sensitivity in TORC1, and a C-terminal protein kinase domain characteristic of PIKK family kinases capped by a short FATC tail important for activity and membrane association. Functionally, TOR integrates nutrient and growth-factor cues to coordinate cellular growth programs: TORC1 (containing Tor1 or Tor2) promotes anabolic metabolism by stimulating translation, transcriptional programs, and ribosome biogenesis while repressing catabolic responses such as autophagy, whereas TOR2 additionally supports TORC2-specific outputs that are rapamycin-insensitive and are required for plasma-membrane homeostasis and polarization of the actin cytoskeleton, thereby linking environmental status to cell-cycle progression and morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: F2J10.19; F2J10_19; target of rapamycin
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