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Peptide sequence: GLECDLAQHL AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 100%
Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis; it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Prosalusin; Salusin-alpha; Salusin-beta; Torsin family 2 member A; torsin family 2, member A; Torsin-2A; Torsin-related protein 1
基因别名: HEMBA1005096; PSEC0218; TOR2A; TORP1; UNQ6408/PRO21181
UniProt ID: (Human) Q8N2E6
Entrez Gene ID: (Human) 27433
分子生物学功能: chaperone