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Bethyl Laboratories
TOX Recombinant Rabbit Monoclonal Antibody (BLR212K)
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产品信息
A700-212
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR212K
抗原
Peptide representing a region between residue 50 and 100 of Human Thymocyte selection-associated high mobility group box protein TOX.
偶联物
形式
Liquid
浓度
250 µg/mL
纯化类型
purified
保存液
BBS, pH 8.2, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunocytochemistry: Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE cell sections.
靶标信息
TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Thymocyte selection-associated high mobility group box protein TOX; thymocyte selection-associated HMG box; Thymus high mobility group box protein TOX
基因别名: 1700007F02Rik; KIAA0808; TOX; TOX1
UniProt ID: (Human) O94900, (Mouse) Q66JW3
Entrez Gene ID: (Human) 9760, (Mouse) 252838
