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Alomone Labs, LTD
TPCN2 Polyclonal Antibody
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TPCN2 Antibody (ACC-072-200UL) in ICC/IF
Expression of Two pore calcium channel protein 2 in rat PC12 cells - Cell surface detection of Two pore calcium channel protein 2 in intact living rat pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-TPCN2 Antibody , (#ACC-072), (1:50), (red). B. Merge of A with the live view of the cell.
产品信息
ACC-072-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KKTLKSIRW(S)LPE(C), corresponding to amino acid residues 187-199 of mouse TPCN2 with replacement of amino acid 192 with serine (S), 2ndluminal loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
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生物信息学
蛋白别名: Two pore calcium channel protein 2; Two pore channel protein 2; two-pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2
基因别名: BC025890; D830047E22Rik; SHEP10; TPC2; TPCN2
UniProt ID: (Human) Q8NHX9, (Mouse) Q8BWC0
Entrez Gene ID: (Human) 219931, (Rat) 309139, (Mouse) 233979
cellular calcium ion homeostasis
smooth muscle contraction
lysosome organization
regulation of autophagy
calcium-mediated signaling
response to vitamin D
ion transmembrane transport
regulation of ion transmembrane transport
release of sequestered calcium ion into cytosol
membrane depolarization during action potential
calcium ion transport
calcium ion transmembrane transport
transport
ion transport
transmembrane transport
