Search
Fabgennix
TPCN2 Polyclonal Antibody, Biotin
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
TPC2-212-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 205-255 on human TPC2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: TPC2; Two pore calcium channel protein 2; Two pore channel protein 2; unnamed protein product; voltage-dependent calcium channel protein TPC2
Gene Aliases: SHEP10; TPC2; TPCN2
UniProt ID: (Human) Q8NHX9
Entrez Gene ID: (Human) 219931
ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
calcium channel activity
protein binding
ligand-gated sodium channel activity
protein kinase binding
voltage-gated channel activity
identical protein binding
NAADP-sensitive calcium-release channel activity
phosphatidylinositol-3,5-bisphosphate binding
intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
ion transport
calcium ion transport
cellular calcium ion homeostasis
smooth muscle contraction
lysosome organization
regulation of autophagy
regulation of exocytosis
receptor-mediated endocytosis of virus by host cell
calcium-mediated signaling
response to vitamin D
ion transmembrane transport
sodium ion transmembrane transport
negative regulation of developmental pigmentation
release of sequestered calcium ion into cytosol
intracellular pH reduction
transmembrane transport
calcium ion transmembrane transport
endocytosis involved in viral entry into host cell
endosome to lysosome transport of low-density lipoprotein particle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support