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Invitrogen
TPH2 Polyclonal Antibody
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TPH2 Antibody (PA5-26185) in ICC/IF
Immunofluorescence analysis of Tryptophan 5-hydroxylase 2 was performed using 70 confluent log phase U-87 MG cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with TPH2 Polyclonal Antibody (Product # PA5-26185) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (P... View More
产品信息
PA5-26185
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 168-193 amino acids from the central region of human TPH2
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse and rat based on sequence homology.
靶标信息
Tryptophan hydroxylase (TPH) is a member of the pterin-dependent aromatic acid hydroxylase family. It catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. TPH is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC119994; Neuronal tryptophan hydroxylase; TPRH; TRPH; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 2
基因别名: ADHD7; AU043594; NTPH; TPH2
UniProt ID: (Human) Q8IWU9, (Mouse) Q8CGV2
Entrez Gene ID: (Human) 121278, (Mouse) 216343
tryptophan 5-monooxygenase activity
iron ion binding
amino acid binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
metal ion binding
circadian rhythm
aromatic amino acid family metabolic process
response to activity
response to nutrient levels
serotonin biosynthetic process
response to estrogen
indolalkylamine biosynthetic process
response to glucocorticoid
response to calcium ion
oxidation-reduction process
cellular response to lithium ion
serotonin biosynthetic process from tryptophan
metabolic process
