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Invitrogen
TPM2 Polyclonal Antibody
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TPM2 Antibody (PA5-143894) in IHC (P)
Immunohistochemistry analysis of TPM2 in paraffin-embedded section of human lung adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with TPM2 Polyclonal antibody (Product # PA5-143894) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjugated Goat Anti-r... View More
产品信息
PA5-143894
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human Tropomyosin 2/TPM2 (KQAEDRCKQLEEEQQALQK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, rat H9C2(2-1) whole cell, mouse skeletal muscle tissue. IHC: human colorectal adenocarcinoma tissue, human lung adenocarcinoma tissue, human placenta tissue, human spleen tissue. Flow: SiHa cell, ANA-1 cell, RH35 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
TPM2 (tropomyosin 2) is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers. TPM2 binds to actin filaments in muscle and non-muscle cells. Plays a central role in association with the troponin complex in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Mutations in this gene can cause nemaline myopathy 4, arthrogryposis dital 1A/2B, and cap myopathy 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-tropomyosin; epididymis secretory protein Li 273; nemaline myopathy type 4; RP11-112J3.4; tropomyosin; Tropomyosin beta chain; Tropomyosin-2
基因别名: AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB; Tpm-2; TPM2; Trop-2
UniProt ID: (Human) P07951, (Rat) P58775, (Mouse) P58774
Entrez Gene ID: (Human) 7169, (Rat) 500450, (Mouse) 22004
