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Immunogen sequence: EMQLKEAKHI AEEADRKYEE VARKLVILE
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 100%.
TPM4 (tropomyosin 4) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 plays a central role in association with the troponin complex in the calcium dependent regulations of vertebrate striated muscle contraction. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory protein Li 108; TM30p1; tropomyosin; Tropomyosin alpha-4 chain; Tropomyosin-4
基因别名: HEL-S-108; TPM4
UniProt ID: (Human) P67936
Entrez Gene ID: (Human) 7171