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Invitrogen
TPSG1 Monoclonal Antibody (279005)
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产品信息
MA5-23979
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
279005
抗原
Mouse myeloma cell line NS0-derived recombinant human Tryptase gamma-1/TPSG1 Arg20-Arg281
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant mouse (rm) MCPT-1, recombinant human (rh) Tryptase alpha, rmTryptase beta -1, rhTryptase beta -2, or rmTryptase-5 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes -alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Serine protease 31; Transmembrane tryptase; Tryptase gamma; tryptase gamma I; tryptase gamma II; Tryptase- gamma
基因别名: PRSS31; TMT; TPSG1; trpA
UniProt ID: (Human) Q9NRR2
Entrez Gene ID: (Human) 25823
