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Invitrogen
TRAF3IP2 Polyclonal Antibody
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产品信息
PA5-22801
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the N-terminus of human ACT.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Suggested positive control: antigen standard for TRAF3IP2 (transient overexpression lysate).
靶标信息
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACT1; Adapter protein CIKS; Connection to IKK and SAPK/JNK; E3 ubiquitin ligase TRAF3IP2; E3 ubiquitin-protein ligase CIKS; NFkB-activating protein ACT1; Nuclear factor NF-kappa-B activator 1; ORF1; ORF2; ORF3; RP3-487J7.3; symbol withdrawn, see C6orf4; TRAF3-interacting protein 2; unnamed protein product
基因别名: ACT1; AI429613; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13; TRAF3IP2
UniProt ID: (Human) O43734, (Mouse) Q8N7N6
Entrez Gene ID: (Human) 10758, (Mouse) 103213
protein polyubiquitination
establishment of T cell polarity
B cell homeostasis
B cell apoptotic process
kidney development
positive regulation of defense response to virus by host
leukocyte activation involved in inflammatory response
transitional two stage B cell differentiation
B cell affinity maturation
eosinophil mediated immunity
protein import into nucleus
inflammatory response
immune response
humoral immune response
heart development
response to xenobiotic stimulus
gene expression
protein ubiquitination
cytokine-mediated signaling pathway
B cell mediated immunity
signal transduction involved in regulation of gene expression
CD40 signaling pathway
T cell differentiation
tumor necrosis factor-mediated signaling pathway
response to cytokine
protein localization to nucleus
intracellular signal transduction
interleukin-17A-mediated signaling pathway
type 2 immune response
T cell activation
neutrophil activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
skin development
mRNA stabilization
lymph node development
spleen development
mucus secretion
protein K63-linked ubiquitination
cellular response to cytokine stimulus
T-helper 17 type immune response
cellular response to interleukin-17
interleukin-17-mediated signaling pathway
protein localization to P-body
negative regulation of interleukin-17-mediated signaling pathway
eosinophil homeostasis
immunoglobulin secretion
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