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This protein is expressed in various tumor cell lines including carcinomas, myeloid or lymphoid malignancies, melanomas or prostate cancer. It is also weakly expressed in kidney and overexpressed in taxol-resistant breast cancer line MDA 435(TR) or the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) or 8226/MDR(10)V.1.
The expression of the cancer-testis antigen Taxol resistanceassociated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxolresistant breast cancer line MDA 435(TR) and the doxorubicinresistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR (10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cancer/testis antigen 24.2; cancer/testis antigen family 24, member 2; chondrosarcoma-associated gene 2/3 protein-like; CSAG family, member 3B; MGC149851; MGC149852; taxol resistance associated gene 3; taxol-resistant-associated gene 3 protein; trag 3
基因别名: CSAG3B; CT24.2; TRAG-3; TRAG3
Entrez Gene ID: (Human) 102723547