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Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 106 kDa O-GlcNAc transferase-interacting protein; milton homolog 1; O-linked N-acetylglucosamine transferase interacting protein 106; OGT(O-Glc-NAc transferase)-interacting protein 106 KDa; Protein Milton; Trafficking kinesin-binding protein 1; trafficking protein, kinesin binding 1
基因别名: KIAA1042; MILT1; OIP106; RGD1307844; TRAK1
UniProt ID: (Human) Q9UPV9
Entrez Gene ID: (Human) 22906, (Rat) 316085