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Invitrogen
TRBP1 Polyclonal Antibody
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TRBP1 Antibody (PA5-120744) in WB
Western blot analysis of TRBP1 in extracts of various cell lines. Samples were incubated with TRBP1 Polyclonal antibody (Product # PA5-120744) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-120744
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1322-1621 of human TARBP1 (NP_005637.3).
偶联物
形式
Liquid
浓度
1.847 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QVESMHGAGN AKKNWQRIQE HFFFATFHPL KDYCLETIFY ILPRLSGLIE DEWITIDKFT RFTDVPLAAG FQWYLSQTQL SKLKPGDWSQ QDIGTNLVEA DNQAEWTDVQ KKIIPWNSRV SDLDLELLFQ DRAARLGKSI SRLIVVASLI DKPTNLGGLC RTCEVFGASV LVVGSLQCIS DKQFQHLSVS AEQWLPLVEV KPPQLIDYLQ QKKTEGYTII GVEQTAKSLD LTQYCFPEKS LLLLGNEREG IPANLIQQLD VCVEIPQQGI IRSLNVHVSG ALLIWEYTRQ QLLSHGDTKP
靶标信息
The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1-a (EF-1-a), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Probable methyltransferase TARBP1; RP5-827C21.5; TAR (HIV) RNA binding protein 1; TAR (HIV) RNA-binding protein 1; TAR RNA loop binding protein; TAR RNA-binding protein 1; TAR RNA-binding protein of 185 kDa; tRNA methyltransferase 3 homolog; TRP-185
基因别名: TARBP1; TRM3; TRP-185; TRP185
UniProt ID: (Human) Q13395
Entrez Gene ID: (Human) 6894
