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Invitrogen

TREX1 Polyclonal Antibody

查看其他25个TREX1抗体

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TREX1 Polyclonal Antibody

产品信息

PA5-117713

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫沉淀 (IP)

1:200-1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human Three-prime repair exonuclease 1 protein (1-270aa)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.4 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2902342

产品详细信息

This antibody has been tested in direct-ELISA

靶标信息

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; Three-prime repair exonuclease 1; TREX1; unnamed protein product

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基因别名: AGS1; CRV; DRN3; HERNS; RVCLS; TREX1

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UniProt ID: (Human) Q9NSU2

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Entrez Gene ID: (Human) 11277

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功能
magnesium ion binding nucleic acid binding DNA binding double-stranded DNA binding single-stranded DNA binding nuclease activity exonuclease activity exodeoxyribonuclease activity protein binding 3'-5'-exodeoxyribonuclease activity DNA binding, bending double-stranded DNA 3'-5' exodeoxyribonuclease activity 3'-5' exonuclease activity hydrolase activity MutLalpha complex binding MutSalpha complex binding adenyl deoxyribonucleotide binding identical protein binding protein homodimerization activity metal ion binding WW domain binding
参与通路
DNA damage checkpoint blood vessel development kidney development adaptive immune response organ or tissue specific immune response activation of immune response macrophage activation involved in immune response lymphoid progenitor cell differentiation immune response in brain or nervous system inflammatory response to antigenic stimulus T cell antigen processing and presentation regulation of immunoglobulin production heart morphogenesis heart process atrial cardiac muscle tissue development generation of precursor metabolites and energy regulation of glycolytic process DNA metabolic process DNA replication DNA repair mismatch repair DNA modification DNA catabolic process DNA recombination inflammatory response immune response cellular response to DNA damage stimulus determination of adult lifespan response to UV regulation of gene expression regulation of fatty acid metabolic process regulation of metabolic process mitotic G1 DNA damage checkpoint transposition, RNA-mediated regulation of type I interferon production regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to reactive oxygen species cellular response to UV cellular response to interferon-beta apoptotic cell clearance regulation of cellular respiration innate immune response regulation of innate immune response establishment of protein localization negative regulation of innate immune response regulation of lipid biosynthetic process regulation of inflammatory response protein stabilization regulation of T cell activation defense response to virus type I interferon signaling pathway negative regulation of type I interferon-mediated signaling pathway regulation of protein complex stability cellular response to type I interferon cellular response to gamma radiation cellular response to hydroxyurea immune complex formation cGAS/STING signaling pathway negative regulation of cGAS/STING signaling pathway DNA synthesis involved in UV-damage excision repair regulation of lysosome organization
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