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Invitrogen
TRIM5 alpha Monoclonal Antibody (K94032_3D8)
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TRIM5 alpha Antibody (MA5-55703) in WB
Western blot analysis of TRIM5 alpha in 15 µg of Jurkat lysate. Sample was run on 6-18% SDS-PAGE under reducing conditions, blotted onto nitrocellulose membrane, and peroxidase conjugated goat anti-mouse IgG was used as the secondary antibody. TRIM5 alpha band was visualized using ECL Western Blotting Substrate. Incubation with primary TRIM5 alpha monoclonal antibody (Product # MA5-55703) at a dilution of 1 µg/mL was used.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-55703
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K94032_3D8
抗原
Recombinant human TRIM5 (immunogen range is 31-270).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: GHSFCQACLT ANHKKSMLDK GESSCPVCRI SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS QEHRGHHTFL TEEVAREYQV KLQAALEMLR QKQQEAEELE ADIREEKASW KTQIQYDKTN VLADFEQLRD ILDWEESNEL QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ GSVMELLQGV DGVIKRTENV TLKKPETFPK
靶标信息
The protein encoded by this gene is a member of the tripartite motif family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coiled-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiquitinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:16276; OTTHUMP00000069812; ring finger protein 88; RING-type E3 ubiquitin transferase TRIM5; TRIM (RBCC) family member; TRIM5 isoform iota; TRIM5 isoform kappa; trim5a; tripartite motif protein TRIM5; tripartite motif-containing protein 5 alpha; unnamed protein product
基因别名: RNF88; TRIM5alpha
UniProt ID: (Human) Q9C035
Entrez Gene ID: (Human) 85363
activation of innate immune response
autophagy
regulation of gene expression
protein ubiquitination
regulation of lipopolysaccharide-mediated signaling pathway
regulation of protein localization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
negative regulation by host of viral release from host cell
innate immune response
positive regulation of transcription, DNA-templated
regulation of viral entry into host cell
negative regulation of viral entry into host cell
defense response to virus
protein K63-linked ubiquitination
antiviral innate immune response
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