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Invitrogen
TRPM6 Polyclonal Antibody
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产品信息
PA5-144221
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Transient receptor potential cation channel subfamily M member 6 protein (740-840AA)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. TRPM6 is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Further, TRPM6 is an essential ion channel and serine/threonine-protein kinase, and is crucial for magnesium homeostasis. TRPM6 has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Mutations in TRPM6 are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. TRPC7 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC7 is probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC7 is also activated by diacylglycerol (DAG). Further, TRPC7 may also be activated by intracellular calcium store depletion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Channel kinase 2; Melastatin-related TRP cation channel 6; Transient receptor potential cation channel subfamily M member 6; transient receptor potential cation channel, subfamily M, member 6
基因别名: CHAK2; HMGX; HOMG; HOMG1; HSH; TRPM6
UniProt ID: (Human) Q9BX84
Entrez Gene ID: (Human) 140803
