Alomone Labs, LTD

TRPM6 (extracellular) Polyclonal Antibody, FITC

Name: TRPM6 (extracellular) Polyclonal Antibody, FITC
Brand: Alomone Labs, LTD
SKU: ACC-046-F-50UL

查看其他3个TRPM6抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

TRPM6 (extracellular) Antibody in Flow Cytometry (Flow)

图: 1 / 3

TRPM6 (extracellular) Antibody (ACC-046-F-50UL) in Flow

Cell surface detection of TRPM6 by direct flow cytometry in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC (#RIC-001-F). (green) Cells + Anti-TRPM6 (extracellular)-FITC Antibody (#ACC-046-F), (5 µg).

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Immunogen image

Immunogen Image TRPM6 (extracellular) Polyclonal Antibody, FITC

产品信息

ACC-046-F-50UL

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

5 µg

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CVKDYDLERGPDEK, corresponding to amino acid residues 802-815 of mouse TRPM6, Extracellular, 1st loop

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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. TRPM6 is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Further, TRPM6 is an essential ion channel and serine/threonine-protein kinase, and is crucial for magnesium homeostasis. TRPM6 has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Mutations in TRPM6 are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. TRPC7 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC7 is probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC7 is also activated by diacylglycerol (DAG). Further, TRPC7 may also be activated by intracellular calcium store depletion.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Channel kinase 2; Melastatin-related TRP cation channel 6; transient receptor potential cation channel 6/channel-kinase 2; Transient receptor potential cation channel subfamily M member 6; transient receptor potential cation channel, subfamily M, member 6

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基因别名: CHAK2; HMGX; HOMG; HOMG1; HSH; TRPM6; TRPM6/CHAK2

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UniProt ID: (Human) Q9BX84, (Mouse) Q8CIR4

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Entrez Gene ID: (Human) 140803, (Rat) 293874, (Mouse) 225997

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功能