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Invitrogen
TRPS1 Polyclonal Antibody
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FIGURE: 1 / 1
TRPS1 Antibody (PA5-96784) in WB
Western blot analysis of TRPS1 in various lysates. Samples were incubated with TRPS1 Polyclonal antibody (Product # PA5-96784) using a dilution of 1:10,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-96784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
44 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPLRNVASEG EGQILEPIGT ESKVSGKNKE FSADQMSENT DQSDAAELNH KEEHSLHVQD PSSSSKKDLK SAVLSEKAGF NYESPSKGGN FPSFPHDEVT DRNMLAFSSP AAGGVCEPLK SPQRAEADDP QDMACTPSGD SLETKEDQKM SPKATEETGQ AQSGQANCQG LSPVSVASKN PQVPSDGGVR LNKSKTDLLV NDNPDPAPLS PELQDFKCNI CGYGYYGNDP TDLIKHFRKY H; Positive Samples: Mouse kidney, Mouse spleen; Cellular Location: Nucleus
Target Information
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: prostate cancer gene product; Tricho-rhino-phalangeal syndrome type I protein; trichorhinophalangeal syndrome I; unnamed protein product; Zinc finger protein GC79; Zinc finger transcription factor Trps1
Gene Aliases: AI115454; AI447310; D15Ertd586e; GC79; LGCR; TRPS1
UniProt ID: (Human) Q9UHF7
Entrez Gene ID: (Human) 7227, (Mouse) 83925
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
protein domain specific binding
sequence-specific DNA binding
metal ion binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of chondrocyte differentiation
negative regulation of transcription, DNA-templated
chondrocyte differentiation
transcription, DNA-templated
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of histone deacetylation
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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