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Invitrogen
TRPV2 Polyclonal Antibody
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TRPV2 Antibody (PA5-18989) in ICC/IF
Immunocytochemistry analysis of TRPV2 using TRPV2 Polyclonal Antibody (Product # PA5-18989) in paraformaldehyde fixed NIH3T3 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing plasma membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18989
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SEEDHLPLQVLQSH) corresponding to the C-terminus amino acids of TRPV2 (aa 743-756).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
靶标信息
VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GRC; growth factor regulated channel; Growth factor-regulated calcium channel; Osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; Transient receptor potential cation channel subfamily V member 2; TrpV2; vanilloid receptor-like protein 1
基因别名: GRC; OTRPC2; Trpv2; VRL-1; Vrl1
UniProt ID: (Mouse) Q9WTR1
Entrez Gene ID: (Mouse) 22368
transport
ion transport
calcium ion transport
apoptotic process
negative regulation of cell proliferation
response to temperature stimulus
response to heat
positive regulation of axon extension
transmembrane transport
calcium ion transmembrane transport
positive regulation of calcium ion import
cation transmembrane transport
