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Alomone Labs, LTD
TRPV2 (VRL1) (extracellular) Polyclonal Antibody
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TRPV2 (VRL1) (extracellular) Antibody (ACC-039-200UL) in ICC/IF
Expression of TRPV2 inRBL cells - Cell surface detection of TRPV2 in intact living rat basophilic leukemia (RBL) cells with Anti-TRPV2 (VRL1) (extracellular) Antibody (#ACC-039), (1:100), followed by goat Anti-rabbit-AlexaFluor-550 secondary Antibody (red), (x100).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
ACC-039-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HQPSLDQPAIPSSKAT, corresponding to amino acid residues 413-428 of rat TRPV2, 1st extracellular loop
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.6 mg/mL
规格
120 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: growth factor regulated channel; growth factor-regulated calcium channel; osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; stretch-activated channel 2B; unnamed protein product; vanilloid receptor-like protein 1; VRL-1
基因别名: GRC; OTRPC2; VRL-1; Vrl1
UniProt ID: (Rat) Q9WUD2, (Mouse) Q9WTR1
Entrez Gene ID: (Rat) 29465, (Mouse) 22368
ion transport
apoptotic process
negative regulation of cell proliferation
response to temperature stimulus
positive regulation of axon extension
transmembrane transport
calcium ion transmembrane transport
positive regulation of calcium ion import
calcium ion import across plasma membrane
positive regulation of cold-induced thermogenesis
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