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TRPV4 Polyclonal Antibody
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产品信息
OST00264G-500UG
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the 1t cytoplasmic loop of mouse TRPV4 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in rat and human.
Specificity of this antibody: TRPV4.
靶标信息
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12; TrpV4; trpv4 channel; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; vanilloid receptor-related osmotically activated channel (Vroac); Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2
基因别名: 0610033B08Rik; BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; TRPV4; VR-OAC; VRL-2; VRL2; VROAC
UniProt ID: (Human) Q9HBA0, (Mouse) Q9EPK8, (Rat) Q9ERZ8
Entrez Gene ID: (Human) 59341, (Mouse) 63873, (Rat) 66026
actin binding
osmosensor activity
protein kinase C binding
cation channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
microtubule binding
stretch-activated, cation-selective, calcium channel activity
protein kinase binding
SH2 domain binding
alpha-tubulin binding
beta-tubulin binding
actin filament binding
nucleotide binding
ion channel activity
ion channel
negative regulation of transcription from RNA polymerase II promoter
diet induced thermogenesis
calcium ion transport
cellular calcium ion homeostasis
cell volume homeostasis
actin filament organization
cell-cell junction assembly
positive regulation of cytosolic calcium ion concentration
osmosensory signaling pathway
response to mechanical stimulus
positive regulation of gene expression
positive regulation of macrophage chemotaxis
negative regulation of neuron projection development
vasopressin secretion
positive regulation of microtubule depolymerization
actin cytoskeleton reorganization
response to insulin
cellular response to heat
hyperosmotic salinity response
glucose homeostasis
positive regulation of vascular permeability
cortical microtubule organization
positive regulation of JNK cascade
microtubule polymerization
regulation of response to osmotic stress
positive regulation of inflammatory response
multicellular organismal water homeostasis
positive regulation of ERK1 and ERK2 cascade
calcium ion import
calcium ion transmembrane transport
cellular response to osmotic stress
cellular hypotonic response
cellular hypotonic salinity response
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
positive regulation of chemokine (C-C motif) ligand 5 production
blood vessel endothelial cell delamination
negative regulation of brown fat cell differentiation
signal transduction involved in regulation of aerobic respiration
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of energy homeostasis
positive regulation of interleukin-6 secretion
transport
ion transport
response to osmotic stress
hypotonic response
transmembrane transport
