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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TSC22D1.
Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: tsc-22-like protein THG-1; TSC22-related-inducible leucine zipper protein 2; unnamed protein product
基因别名: THG-1; THG1; TILZ2
UniProt ID: (Human) Q9Y3Q8
Entrez Gene ID: (Human) 81628