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Invitrogen
TSG Polyclonal Antibody
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TSG Antibody (PA5-78540) in IHC (P)
TSG Polyclonal Antibody detects TWSG1 protein at cytosol on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. TSG Polyclonal Antibody (Product # PA5-78540) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78540
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human TWSG1. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: A549
Predicted Reactivity: Rat (97%), Xenopus laevis (88%), Chicken (98%), Rhesus Monkey (100%), Bovine (99%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: involved in molecular signalling during spermatogenesis; secreted BMP-binding protein; twisted gastrulation homolog 1; unnamed protein product
基因别名: 1810013J15Rik; 9030422N06Rik; D17Ertd403e; TSG; Twg
UniProt ID: (Human) Q9GZX9, (Mouse) Q9EP52
Entrez Gene ID: (Human) 57045, (Mouse) 65960
ossification
mesoderm formation
negative regulation of cytokine production
salivary gland morphogenesis
tissue development
hemopoiesis
cell differentiation
BMP signaling pathway
regulation of BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
camera-type eye development
negative regulation of osteoblast differentiation
positive regulation of SMAD protein import into nucleus
negative regulation of CD4-positive, alpha-beta T cell activation
negative regulation of CD4-positive, alpha-beta T cell proliferation
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