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Invitrogen
TSKU Polyclonal Antibody
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TSKU Antibody (PA5-48041) in IHC (P)
Immunohistochemical analysis of TSKU in immersion fixed paraffin-embedded sections of human colon cancer tissue. Samples were incubated in TSKU polyclonal antibody (Product # PA5-48041) using a dilution of 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-basic. Tissue was stained using the Anti-Goa... View More
产品信息
PA5-48041
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human Tsukushi/TSK Thr17-Leu353
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse TSK is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2-induced gene 4 protein; leucine rich repeat containing 54; Leucine-rich repeat-containing protein 54; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog
基因别名: E2IG4; LRRC54; TSK; TSKU; UNQ850/PRO1788
UniProt ID: (Human) Q8WUA8
Entrez Gene ID: (Human) 25987
