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Invitrogen
TSN Polyclonal Antibody
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FIGURE: 1 / 1
TSN Antibody (PA5-101173) in WB
Western blot analysis of TSN in extracts from various samples. Samples were incubated with TSN polyclonal antibody (Product # PA5-101173). Lane 1: A549 cells, blocked with antigen-specific peptides; Lane 2: A549 cells; Lane 3: Mouse spleen; Lane 4: Hela cells; Lane 5: P19 cells.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101173
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TSN(Accession Q15631), corresponding to amino acid residues L101-L151.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TSN.
Target Information
Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3PO; Component 3 of promoter of RISC; TB-RBP; Testis/brain RNA-binding protein; testis/brain-RNA-binding protein; Translin
Gene Aliases: 2610034C24Rik; AU040286; C3PO; TB-RBP; TSN
UniProt ID: (Mouse) Q62348
Entrez Gene ID: (Rat) 60381, (Mouse) 22099
single-stranded DNA binding
RNA binding
mRNA binding
endoribonuclease activity
protein complex binding
sequence-specific DNA binding
DNA binding
nuclease activity
endonuclease activity
protein binding
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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