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NeoBiotechnologies
TTF-1/NKX2.1 (Thyroid & Lung Epithelial Marker) Recombinant Rabbit Monoclonal Antibody (MSVA-312R)
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TTF-1/NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody (7080-RBM37-P1) in IHC (P)
Homeobox protein Nkx-2.1 Rabbit Recombinant Monoclonal Antibody (MSVA-312R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
产品信息
7080-RBM37-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSVA-312R
抗原
Recombinant full-length human NXK2-1 (TTF-1) protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Membrane.
Positive control: Lung: A strong staining should be seen in endothelial cells, and at least a weak to moderate membranous CD141 staining should be seen in alveolar macrophages.
Tissue specificity: Endothelial cells are unique in synthesizing thrombomodulin.
靶标信息
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TTF-1; TTF1
基因别名: BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
UniProt ID: (Human) P43699
Entrez Gene ID: (Human) 7080
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
core promoter binding
intronic transcription regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
enzyme binding
transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of blood volume by renin-angiotensin
transcription, DNA-templated
phospholipid metabolic process
axon guidance
brain development
endoderm development
locomotory behavior
feeding behavior
response to hormone
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
globus pallidus development
hippocampus development
cerebral cortex cell migration
forebrain dorsal/ventral pattern formation
forebrain neuron fate commitment
cerebral cortex GABAergic interneuron differentiation
pituitary gland development
lung development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
thyroid gland development
forebrain development
developmental induction
response to lipopolysaccharide
Leydig cell differentiation
hyperosmotic salinity response
positive regulation of circadian rhythm
response to ethanol
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
development of primary female sexual characteristics
rhythmic process
anatomical structure formation involved in morphogenesis
oligodendrocyte differentiation
lung saccule development
epithelial tube branching involved in lung morphogenesis
Clara cell differentiation
Type II pneumocyte differentiation
