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Immunogen sequence: QEDSNLSEEL SHSAFGQAFS KILHCLARPE ARRGNVKDAV LKDLGDLIEA TGFDRLFEGT GARLRGMPET LGQVAKALEK Y
Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 57%.
The DNA replication (origin) licensing system is necessary for duplicating the genome in each cell cycle. Geminin is a protein that prevents DNA replication by blocking the MCM complex incorporation into prereplication complex (pre-RC). It is absent during G1 phase and accumulates during S, G2, and M phases of mitosis. It is then degraded during the metaphase-anaphase trasition allowing replication to occur during subsequent cycles. Geminin has also been implicated in maintaining integrity of the male germline genome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ23263; Tel2 interacting protein 2 homolog; TELO2-interacting protein 2
基因别名: C8orf41; MRT39; TTI2
UniProt ID: (Human) Q6NXR4
Entrez Gene ID: (Human) 80185