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Invitrogen
TTLL10 Polyclonal Antibody
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产品信息
PA5-31631
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human TTLL10. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, NIH-3T3.
Predicted reactivity: Mouse (82%), Rat (82%), Rhesus Monkey (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The TTLL10 gene encodes a protein that functions as a polyglycylase, playing an important role in the modification of nucleosome assembly protein 1 (NAP1) both in vivo and in vitro. This enzymatic activity is dependent on the presence of ATP and is abolished in mutant forms where the glutamate in the active site is replaced by valine. TTLL10 specifically incorporates glycine into recombinant NAP1 at Glu residues 359 and 360. This modification process likely has implications for protein interactions and cellular processes involving NAP1. Additionally, TTLL10 can perform tubulin glycylation when co-expressed with TTLL8, suggesting a complex interplay between these enzymes in cellular microtubule dynamics.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Inactive polyglycylase TTLL10; Protein polyglycylase TTLL10; tubulin tyrosine ligase-like family member 10; tubulin tyrosine ligase-like family, member 10; tubulin tyrosine ligase-like family, member 5; Tubulin--tyrosine ligase-like protein 10
基因别名: 4833412E22Rik; 4930595O22Rik; AU022799; BC042775; TTLL10; TTLL5
UniProt ID: (Human) Q6ZVT0, (Mouse) A4Q9F3
Entrez Gene ID: (Human) 254173, (Mouse) 330010
protein binding
ATP binding
protein-glycine ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
