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Invitrogen
TUBB4B/TUBB2A/TUBB2B Recombinant Rabbit Monoclonal Antibody (10B7)
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TUBB4B/TUBB2A/TUBB2B Antibody (MA572468) in IHC (P)
Immunohistochemistry analysis of TUBB4B/TUBB2A/TUBB2B on paraffin-embedded Mouse Cerebrum tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with TUBB4B/TUBB2A/TUBB2B Recombinant Monoclonal (Product # MA572468) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
产品信息
MA572468
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10B7
抗原
KLH conjugated synthetic peptide derived from human beta 4B Tubulin.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The TUBB4B, TUBB2A, and TUBB2B genes encode distinct beta-tubulin isoforms that combine with alpha-tubulin to form microtubules, essential cytoskeletal structures involved in cell shape, intracellular transport, cell division, and signaling. TUBB4B (tubulin beta 4B class IVb), located on chromosome 9, contributes to microtubule assembly and stabilization and is highly expressed in the brain, where it is critical for neural development, with mutations linked to neurological and developmental disorders. TUBB2A (tubulin beta 2A class IIa), located on chromosome 6, is ubiquitously expressed and particularly important in rapidly dividing tissues such as developing neurons and cancer cells; alterations in its expression or function are associated with cancer progression and neurological disease. TUBB2B (tubulin beta 2B class IIb), also located on chromosome 6, plays a key role in microtubule dynamics, neurodevelopment, and neuronal migration and is predominantly expressed in the brain, with mutations associated with cortical malformations and other neurological conditions. Together, differential expression and functional specialization of these beta-tubulin isoforms allow fine-tuning of microtubule behavior, and abnormalities in these genes contribute to a range of developmental, neurological, and cancer-related disorders, making them important targets for understanding disease mechanisms and therapeutic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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