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Agrisera
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Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 150 µL of sterile water.
Specific Species Reactivity: Tomato yellow leaf curl virus coat 15.4 kDa
TYLCV C2 is a complementary-sense open reading frame in the circular single-stranded DNA genome of Tomato yellow leaf curl virus that encodes the multifunctional transcription activator protein (TrAP), which accumulates predominantly in the host cell nucleus via an arginine-rich nuclear localization signal embedded in an N-terminal basic region. The C2/TrAP polypeptide is a small (~15 kDa) protein (about 129 amino acids in representative begomoviruses) with a modular organization that includes (i) an N-terminal basic/NLS segment important for nuclear targeting and activity, (ii) a central cysteine/histidine-rich zinc-binding, zinc finger-like region required for key regulatory functions, and (iii) a C-terminal acidic transcriptional activation domain. Functionally, TYLCV C2/TrAP is a central pathogenicity determinant that reprograms host transcription to promote infection and symptom development, and it also contributes to suppression of host antiviral RNA silencing (post-transcriptional gene silencing), consistent with the requirement for nuclear localization for full suppressor activity and for induction of disease-associated responses in planta.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AC2; AL2; C2; L2; transcriptional activation protein; transcriptional activator protein; TrAP