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Invitrogen
TYRO3 Recombinant Rabbit Monoclonal Antibody (14H68L29)
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TYRO3 Antibody (703295) in ICC/IF
For immunofluorescence analysis, PC-12 cells were fixed and permeabilized for detection of endogenous TYRO3 using Anti-TYRO3 Recombinant Rabbit Monoclonal Antibody (Product # 703295, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). Panel a-c) shows representative undifferentiated cells that were stained for detection and localization of T... View More
产品信息
703295
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
14H68L29
抗原
Protein corresponding to human TYRO3 [aa790-aa890]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Human, Monkey, Pig, Bovine, Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bruton agammaglobulinemia tyrosine kinase; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; tyro 3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
基因别名: Brt; BYK; DTK; Etk-2; Rek; RSE; SKY; TIF; TYRO3
UniProt ID: (Human) Q06418, (Rat) P55146
Entrez Gene ID: (Human) 7301, (Rat) 25232
natural killer cell differentiation
cell adhesion
signal transduction
spermatogenesis
phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
forebrain cell migration
signal transduction by protein phosphorylation
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
viral entry into host cell
protein autophosphorylation
negative regulation of inflammatory response
negative regulation of lymphocyte activation
vagina development
neuron cellular homeostasis
platelet aggregation
protein phosphorylation
