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Invitrogen
Tau (isoform 4) Monoclonal Antibody (3E2)
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Tau (isoform 4) Antibody (MA571727) in IHC (P)
Immunohistochemistry analysis of Tau (isoform 4) on paraffin-embedded Human Duodenum tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with Tau (isoform 4) Monoclonal (Product # MA571727) using a dilution at 1:200 overnight at 4°C. Followed by conjugated Goat Anti-Mouse IgG antibody (Green). DAPI (Blue) was used to stain the cell nuclei.
产品信息
MA571727
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
3E2
抗原
Recombinant Tau isoform 4 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tau proteins are microtubule associated proteins encoded by the MAPT gene, with alternative splicing of MAPT pre mRNA generating six Tau isoforms in the human central nervous system, including Tau isoform 4, which is particularly relevant to neurological health and disease. Tau isoform 4 contains microtubule binding domains and is distinguished by specific exon composition, most notably inclusion of exon 10, which influences microtubule binding strength and stability, thereby contributing to its unique structural and functional properties. Functionally, Tau isoform 4 plays a critical role in the assembly and stabilization of neuronal microtubules, supporting axonal integrity, intracellular transport, and neuronal morphology. Under pathological conditions, abnormal splicing or post translational modifications such as hyperphosphorylation can impair Tau function, promoting the formation of insoluble neurofibrillary tangles, a hallmark of Alzheimers disease and other tauopathies; consequently, understanding the role of Tau isoform 4 provides important insight into neurodegenerative mechanisms and potential therapeutic strategies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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