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Invitrogen
Thrombospondin 1 Recombinant Rabbit Monoclonal Antibody (K01_2P75)
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Thrombospondin 1 Antibody (MA564220) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Thrombospondin 1 in paraffin-embedded Human Cholangiocarcinoma. Samples were incubated with Thrombospondin 1 recombinant monoclonal (Product # MA564220). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
产品信息
MA564220
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2P75
抗原
Recombinant protein of human Thrombospondin 1 (aa 547-1170).
偶联物
形式
Liquid
浓度
0.60 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PIDGCLSNPC FAGVKCTSYP DGSWKCGACP PGYSGNGIQC TDVDECKEVP DACFNHNGEH RCENTDPGYN CLPCPPRFTG SQPFGQGVEH ATANKQVCKP RNPCTDGTHD CNKNAKCNYL GHYSDPMYRC ECKPGYAGNG IICGEDTDLD GWPNENLVCV ANATYHCKKD NCPNLPNSGQ EDYDKDGIGD ACDDDDDNDK IPDDRDNCPF HYNPAQYDYD RDDVGDRCDN CPYNHNPDQA DTDNNGEGDA CAADIDGDGI LNERDNCQYV YNVDQRDTDM DGVGDQCDNC PLEHNPDQLD SDSDRIGDTC DNNQDIDEDG HQNNLDNCPY VPNANQADHD KDGKGDACDH DDDNDGIPDD KDNCRLVPNP DQKDSDGDGR GDACKDDFDH DSVPDIDDIC PENVDISETD FRRFQMIPLD PKGTSQNDPN WVVRHQGKEL VQTVNCDPGL AVGYDEFNAV DFSGTFFINT ERDDDYAGFV FGYQSSSRFY VVMWKQVTQS YWDTNPTRAQ GYSGLSVKVV NSTTGPGEHL RNALWHTGNT PGQVRTLWHD PRHIGWKDFT AYRWRLSHRP KTGFIRVVMY EGKKIMADSG PIYDKTYAGG RLGLFVFSQE MVFFSDLKYE CRDP
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 54%, Pig - 99%, Cynomolgus monkey - 99%.
靶标信息
Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glycoprotein G; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1
基因别名: tbsp1; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1
UniProt ID: (Human) P07996
Entrez Gene ID: (Human) 7057, (Mouse) 21825
phosphatidylserine binding
glycoprotein binding
fibronectin binding
integrin binding
calcium ion binding
protein binding
heparin binding
fibroblast growth factor binding
low-density lipoprotein particle binding
identical protein binding
laminin binding
proteoglycan binding
transforming growth factor beta binding
fibrinogen binding
collagen V binding
extracellular matrix binding
activation of MAPK activity
response to hypoxia
negative regulation of endothelial cell proliferation
negative regulation of cell-matrix adhesion
sprouting angiogenesis
chronic inflammatory response
platelet degranulation
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
inflammatory response
immune response
response to unfolded protein
cell cycle arrest
cell adhesion
response to glucose
positive regulation of endothelial cell migration
negative regulation of endothelial cell migration
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of nitric oxide mediated signal transduction
negative regulation of cGMP-mediated signaling
negative regulation of plasminogen activation
positive regulation of macrophage chemotaxis
positive regulation of fibroblast migration
cell migration
negative regulation of angiogenesis
peptide cross-linking
positive regulation of blood coagulation
extracellular matrix organization
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of cGMP metabolic process
response to magnesium ion
response to progesterone
negative regulation of interleukin-12 production
positive regulation of transforming growth factor beta1 production
cellular response to heat
response to endoplasmic reticulum stress
protein O-linked fucosylation
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of phosphorylation
response to drug
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
engulfment of apoptotic cell
positive regulation of translation
positive regulation of angiogenesis
behavioral response to pain
positive regulation of chemotaxis
response to calcium ion
negative regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of endothelial cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway
outflow tract morphogenesis
endocardial cushion development
growth plate cartilage development
response to mechanical stimulus
positive regulation of cell-substrate adhesion
blood vessel morphogenesis
positive regulation of transforming growth factor beta production
cellular response to nitric oxide
