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Invitrogen
Tolbutamide Recombinant Mouse Monoclonal Antibody (1D4)
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FIGURE: 1 / 1
Tolbutamide Antibody (MA566273) in SDS-PAGE
SDS-PAGE characterization of Tolbutamide under reducing conditions. Lane M: Protein marker (kDa); Lane TLM: Purified Tolbutamide Recombinant Monoclonal (Product # MA566273). Tolbutamide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-663.
Product Details
MA566273
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1D4
Immunogen
Conjugate of TLM hapten and KLH.
Conjugate
Form
Liquid
Concentration
3.5 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Tolbutamide is a first-generation sulfonylurea oral hypoglycemic agent used primarily in the treatment of type-2 diabetes. It functions by stimulating insulin secretion through binding to the high-affinity subunit SUR1 of the beta-cell ATP-sensitive potassium channel (KATP channel). The gene encoding the SUR1 subunit is located on chromosome 11p15.1 and is part of the ABCC8 gene, which plays a critical role in insulin regulation. Structurally, tolbutamide is characterized by its sulfonylurea moiety, which is essential for its hypoglycemic activity. Recent studies have explored the synthesis of tolbutamide derivatives with NO-donor properties, aiming to enhance its biological profile by linking it with furoxan derivatives or classical nitrooxy functions, potentially offering improved therapeutic benefits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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