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Invitrogen
Torasemide Recombinant Mouse Monoclonal Antibody (3F3)
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Torasemide Antibody (MA566270) in SDS-PAGE
SDS-PAGE characterization of Torasemide under reducing conditions. Lane M: Protein marker (kDa); Lane TSM: Purified Torasemide Recombinant Monoclonal (Product # MA566270). Torasemide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-670.
产品信息
MA566270
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3F3
抗原
Conjugate of TSM hapten and KLH.
偶联物
形式
Liquid
浓度
3.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Torasemide, also known as torsemide, is a loop diuretic primarily used for the treatment of congestive heart failure and arterial hypertension. It functions by inhibiting the Na+/K+/2Cl- cotransporter in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water. Torasemide has a higher bioavailability (>80%) and a longer elimination half-life (3 to 4 hours) compared to furosemide, making it effective for long-term management of fluid overload conditions. The gene location and structure of torasemide are not directly applicable as it is a synthetic compound rather than a biologically derived biosimilar. However, its pharmacokinetics and pharmacodynamics have been extensively studied, showing a sigmoid E(max) model for its natriuretic rate versus excretion rate. Synonyms for torasemide include torsemide, Demadex, and others. It is important to note that torasemide has been tested negative in genotoxicity assays but was weakly carcinogenic to female rats in some studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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