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Invitrogen
Trefoil Factor 3 Monoclonal Antibody (5UCLNT3), eBioscience™
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Trefoil Factor 3 Antibody (14-4758-82) in IHC (P)
Immunohistochemistry of formalin-fixed paraffin embedded rat small intestine tissue using 0.5 µg/mL of Anti-Mouse/Rat Trefoil Factor 3 Purified followed by Anti-Mouse IgG Biotin, Streptavidin-HRP, and DAB visualization. Nuclei are counterstained with hematoxylin.
产品信息
14-4758-82
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
5UCLNT3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: The monoclonal antibody 5UCLNT3 recognizes mouse and rat Trefoil Factor 3. Trefoil Factor 3 (TFF3) is a member of the trefoil family, which are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. TFF3 is a small peptide hormone secreted by mucus-producing cells and by epithelial cells of multiple tissues, including the gastrointestinal tract, kidney, and breast. TFF3 plays an essential role in both mucosal surface maintenance and restitution. TFF3 facilitates restoration of the intestinal epithelium as a protective barrier against injury by inhibiting apoptosis and promoting survival and migration of epithelial cells. TFF3 also plays a role in inducing airway epithelial ciliated cell differentiation. Levels of TFF3 change after renal injury and urinary levels can be used as a biomarker for kidney tubular injury. TFF3 may also play a role in breast tumor progression and tumor cell dissemination.
Applications Reported: This 5UCLNT3 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and microscopy.
Applications Tested: This 5UCLNT3 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded rat tissue using low pH antigen retrieval and can be used at less than or equal to 0.5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Intestinal trefoil factor; mITF; Polypeptide P1.B; rITF; rP1.B; Trefoil factor 3
基因别名: ITF; mITF; Tff3
UniProt ID: (Mouse) Q62395, (Rat) Q03191
Entrez Gene ID: (Mouse) 21786, (Rat) 25563
