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TrkA/TrkB/TrkC Recombinant Rabbit Monoclonal Antibody (RM423)

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TrkA/TrkB/TrkC Recombinant Rabbit Monoclonal Antibody (RM423)

产品信息

MA5-36218

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:200
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

RM423

抗原

A peptide corresponding to the C-terminus of human TRK
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.08 mg/mL

规格

8 µg

纯化类型

Protein A

保存液

PBS with 50% glycerol, 1% BSA

内含物

0.09% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2884052

产品详细信息

MA5-36218 reacts to human TRK. This antibody may also react to mouse or rat TRK, as predicted by immunogen homology.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp140trk; GP145-TrkB; GP145-TrkC; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; NTRK2; NTRK3; Oncogene TRK; p140-TrkA; splice variant; TEL-TrkC fusion protein; trk tyrosine-specific protein kinase; Trk-A; Trk-B; Trk-C; TRK1-transforming tyrosine kinase protein; TrkB; TrkB tyrosine kinase; TrkB-T-Shc; trkC; TrkC tyrosine kinase; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tropomyosin-related kinase B; truncated trkB; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B; tyrosine kinase receptor C; unnamed protein product

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基因别名: DEE58; EIEE58; gp145(trkC); GP145-TrkB; GP145-TrkC; MTC; NTRK1; NTRK2; NTRK3; OBHD; p140-TrkA; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKC

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UniProt ID: (Human) P04629, (Human) Q16620, (Human) Q16288

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Entrez Gene ID: (Human) 4914, (Human) 4915, (Human) 4916

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功能
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding protease binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity p53 binding
参与通路
vasculogenesis neuron migration transmembrane receptor protein tyrosine kinase signaling pathway nervous system development learning circadian rhythm feeding behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development glutamate secretion regulation of metabolic process neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system cell differentiation neuron differentiation brain-derived neurotrophic factor receptor signaling pathway neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of protein kinase B signaling positive regulation of protein kinase B signaling positive regulation of synapse assembly retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis protein phosphorylation spermatogenesis axon guidance learning or memory negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development peptidyl-tyrosine phosphorylation olfactory nerve development B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway negative regulation of apoptotic process positive regulation of programmed cell death positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity neuron apoptotic process response to hydrostatic pressure response to electrical stimulus positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus cell communication heart development positive regulation of cell migration positive regulation of apoptotic process response to ethanol animal organ development neuron fate specification axon extension involved in regeneration positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation system development positive regulation of positive chemotaxis response to corticosterone lens fiber cell differentiation cellular response to retinoic acid cochlea development postsynaptic density assembly regulation of presynapse assembly regulation of neural precursor cell proliferation
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