Invitrogen

TrkB Recombinant Rabbit Monoclonal Antibody (0S2K4)

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TrkB Recombinant Rabbit Monoclonal Antibody (0S2K4)

产品信息

MA5-51308

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000-1:10,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

0S2K4

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 32-430 of human TrkB (NP_001018074.1).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.00 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3093891

产品详细信息

Immunogen sequence: CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH

靶标信息

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase

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基因别名: GP145-TrkB/GP95-TrkB; Ntrk2; RATTRKB1; Tkrb; trk-B; Trkb; TRKB1

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UniProt ID: (Mouse) P15209, (Rat) Q63604

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Entrez Gene ID: (Mouse) 18212, (Rat) 25054

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功能
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein homodimerization activity neurotrophin binding ephrin receptor binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity transmembrane signal receptor
参与通路
vasculogenesis neuron migration protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation peptidyl-tyrosine phosphorylation regulation of metabolic process central nervous system neuron development cerebral cortex development cell differentiation neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus positive regulation of glucocorticoid receptor signaling pathway negative regulation of anoikis inflammatory response aging circadian rhythm response to light stimulus response to auditory stimulus cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus
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