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TrkCT1 Polyclonal Antibody
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图: 1 / 3
TrkCT1 Antibody (600-401-993) in WB
Mouse cortex lysate was immunoprecipitated with anti-TrkCT1 antibody and further blotted with affinity purified anti-TrkCT1. Lane 1 is wild-type cortex lysate, Lane 2 is Tamalin knock-out cortex lysate, and Lane 3 is TrkCT1 knock-out cortex lysate. The membrane was probed with the primary antibody at a 1:6,000 dilution. Personal Communication, V. Coppola, CCR-NCI, Frederick, MD.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-993
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against mouse TrkCT1 protein. A BLAST analysis was used to suggest cross-reactivity with TrkCT1 protein from human, mouse and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
靶标信息
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; mTrkC NC1; mTrkC NC2; neural receptor protein-tyrosine kinase (trkC); neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NTRK3; slow nerve growth factor receptor; slow nerve growth factor receptor; TRKC(ki39); splice variant; splicing variant of the Ntrk3 receptor; TEL-TrkC fusion protein; trk-C; TrkC; trkC tyrosine kinase; TrkC(ki14); slow nerve growth factor receptor; tyrosine kinase receptor C; unnamed protein product
基因别名: gp145(trkC); GP145-TrkC; Ntrk3_tv3; TRKC
UniProt ID: (Human) Q16288, (Rat) Q03351, (Mouse) Q6VNS1
Entrez Gene ID: (Human) 4916, (Rat) 29613, (Mouse) 18213
p53 binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
protein binding
ATP binding
neurotrophin binding
transmembrane receptor protein serine/threonine kinase activity
GPI-linked ephrin receptor activity
neuron migration
transmembrane receptor protein tyrosine kinase signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of neuron projection development
neuronal action potential propagation
myelination in peripheral nervous system
positive regulation of cell migration
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
positive regulation of MAPK cascade
response to ethanol
ephrin receptor signaling pathway
animal organ development
neuron fate specification
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
system development
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of protein kinase B signaling
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
postsynaptic density assembly
regulation of presynapse assembly
cellular response to nerve growth factor stimulus
regulation of neural precursor cell proliferation
cell communication
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