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Invitrogen
TrxR1 Recombinant Rabbit Monoclonal Antibody (20F6)
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图: 1 / 15
TrxR1 Antibody (MA572717) in ICC/IF
Immunocytochemistry analysis of TrxR1 in A549 cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with TrxR1 Recombinant Monoclonal (Product # MA572717 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA572717
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
20F6
抗原
A synthesized peptide derived from human TR.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol, 0.05% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; KM-102-derived reductase-like factor; MGC9145; NADPH-dependent thioredoxin reductase; Peroxidase TXNRD1; selenoprotein oxidoreductase; Thioredoxin reductase 1, cytoplasmic; Thioredoxin reductase TR1; TR; TR alpha
基因别名: GRIM12; KDRF; TR; TR1; TrxR1; TXNRD1
UniProt ID: (Mouse) Q9JMH6
Entrez Gene ID: (Rat) 58819, (Mouse) 50493
thioredoxin-disulfide reductase activity
mercury (II) reductase activity
NAD(P)H oxidase activity
selenate reductase activity
protein homodimerization activity
mercury ion binding
flavin adenine dinucleotide binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
reductase
mesoderm formation
placenta development
glutathione metabolic process
response to oxidative stress
gastrulation
cell proliferation
response to selenium ion
positive regulation of cell death
selenocysteine metabolic process
methylmercury metabolic process
response to drug
benzene-containing compound metabolic process
hydrogen peroxide catabolic process
cell redox homeostasis
response to axon injury
detoxification of mercury ion
protein tetramerization
response to hyperoxia
oxidation-reduction process
halogen metabolic process
NADPH oxidation
cellular response to copper ion
cellular response to hyperoxia
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