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Invitrogen
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Anionic trypsin II; Anionic trypsin-2; Anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; Pretrypsinogen II; protease serine 2 preproprotein; protease, serine, 2; protease, serine, 2 (trypsin 2); Serine protease 2; trypsin 2; Trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20
基因别名: PRSS2; Ta; Tesp4; TRY2; TRY8; TRYP; TRYP2
UniProt ID: (Human) P07478, (Mouse) P07146
Entrez Gene ID: (Human) 5645, (Mouse) 22072