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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Ubiquitin B Antibodies

          Abnova

          UBB Recombinant Rabbit Monoclonal Antibody

          View all (15) Ubiquitin B antibodies

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          Cite UBB Recombinant Rabbit Monoclonal Antibody

          • Antibody Testing Data (3)
          UBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          UBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          FIGURE: 1 / 3

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          UBB Antibody (RAB02153) in IHC (P)

          Immunohistochemical staining (Formalin/PFA-fixed paraffin-embedded sections) of human colon cancer with UBB recombinant monoclonal antibody, clone R06-2H7 (Product # RAB02153). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          UBB Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          UBB Antibody in Western Blot (WB)
          UBB Antibody in Western Blot (WB)

          Product Details

          RAB02153

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:100
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Expression System

          CHO cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to human UBB.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          Affinity chromatography

          Storage buffer

          50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol

          Contains

          0.01% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3710704

          Target Information

          Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: epididymis secretory protein Li 50; HUBCEP52; MGC127041; polyubiquitin B; Polyubiquitin-B; RPL40; ubiquitin C

          View more View less

          Gene Aliases: AL033289; HEL-S-50; Rps27a; Uba52; UBB; Ubb2; UBC

          View more View less

          UniProt ID: (Human) P0CG47, (Mouse) P0CG49, (Rat) P0CG51

          View more View less

          Entrez Gene ID: (Human) 7314, (Mouse) 22187, (Rat) 192255

          View more View less

          Function(s)
          protein binding
          Process(es)
          male meiosis I female meiosis I male gonad development female gonad development ubiquitin homeostasis hypothalamus gonadotrophin-releasing hormone neuron development mitochondrion transport along microtubule neuron projection morphogenesis regulation of mitochondrial membrane potential adipose tissue development fat pad development regulation of proteasomal protein catabolic process seminiferous tubule development energy homeostasis regulation of neuron death positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPK activity protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding stimulatory C-type lectin receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway glycogen biosynthetic process transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transforming growth factor beta receptor signaling pathway Notch signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade fibroblast growth factor receptor signaling pathway regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death Wnt signaling pathway endosomal transport macroautophagy viral life cycle virion assembly translesion synthesis negative regulation of transforming growth factor beta receptor signaling pathway anaphase-promoting complex-dependent catabolic process positive regulation of protein ubiquitination regulation of type I interferon production negative regulation of type I interferon production tumor necrosis factor-mediated signaling pathway nucleotide-excision repair, DNA incision ion transmembrane transport TRIF-dependent toll-like receptor signaling pathway interstrand cross-link repair NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway ERBB2 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway error-prone translesion synthesis DNA damage response, detection of DNA damage protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of mRNA stability cellular protein metabolic process innate immune response positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Wnt signaling pathway, planar cell polarity pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia nucleotide-binding oligomerization domain containing signaling pathway global genome nucleotide-excision repair error-free translesion synthesis intracellular transport of virus negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signal transduction by p53 class mediator positive regulation of protein monoubiquitination
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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