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Invitrogen
UBB (mutant) Monoclonal Antibody (83456)
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产品信息
MA5-61756
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
83456
抗原
E. coli-derived recombinant human Ubiquitin+1, Met1-Gly75, YADLREDPDRQDHHPGSGAQ (C-terminal sequence generated by a frameshift)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
UBB (ubiquitin B) is a gene that encodes ubiquitin, a small regulatory protein that is ubiquitously expressed in eukaryotic cells. Ubiquitin plays a critical role in various cellular processes, including protein degradation, DNA repair, cell cycle regulation, and response to oxidative stress, by tagging proteins for degradation via the ubiquitin-proteasome system. Mutations in the UBB gene can lead to the production of defective ubiquitin proteins that can disrupt these essential cellular processes. One notable mutant form, UBB+1, is produced through a molecular process called frameshift mutation, which can occur during transcription. This mutant ubiquitin acts as a proteasome inhibitor rather than a substrate, leading to the accumulation of misfolded or damaged proteins. Such accumulation is associated with neurodegenerative diseases, including Alzheimer's disease and other forms of dementia, where impaired protein degradation contributes to disease pathology. Understanding the impact of UBB mutations, particularly UBB+1, is crucial for developing therapeutic strategies aimed at enhancing proteasome function and mitigating the effects of protein aggregation in neurodegenerative disorders. Research into UBB mutants also provides broader insights into the mechanisms of protein homeostasis and the potential for targeting the ubiquitin-proteasome system in various diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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