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UBC7/13/14/Ubiquitin-conjugating enzyme E2 7/13/14 Polyclonal Antibody
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UBC7/13/14/Ubiquitin-conjugating enzyme E2 7/13/14 Antibody (AS23-4886) in WB
Samples: 1 - 30 µg total proteins of Arabidopsis thaliana 10-day-old seedlings; wild type 2 - 30 µg total proteins of Arabidopsis thaliana 10-day-old seedlings; ubc 7-1 3 - 30 µg total proteins of Arabidopsis thaliana 10-day-old seedlings; ubc 13-1 4 - 30 µg total proteins of Arabidopsis thaliana 10-day-old seedlings; ubc 14-1 5 - 30 µg total proteins of Arabidopsis thaliana 10-day-old seedlings; ubc 7/13/1... View More
产品信息
AS23-4886
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana UBC7.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
UBC7/13/14 encode members of the ubiquitin-conjugating (E2) enzyme family that operate predominantly in the cytoplasm and nucleus to transfer ubiquitin from E1 to substrate proteins in cooperation with E3 ligases. UBC7 (UBE2G2) is an ~18-20 kDa E2 with a conserved UBC catalytic core containing the active-site cysteine; it is enriched at endoplasmic reticulum-associated sites where it supports ER-associated degradation (ERAD) of misfolded or regulated ER proteins and can promote Lys48-linked polyubiquitin chain formation in vitro, including pathways controlling sterol-regulated turnover of metabolic enzymes. UBC13 (UBE2N) is a canonical E2 that forms an obligate heterodimer with a catalytically inactive E2-variant partner (e.g., MMS2 or UEV1A) to assemble Lys63-linked polyubiquitin chains that function primarily as non-proteolytic signals, with documented roles separating DNA damage tolerance/repair versus NF-kappaB signaling depending on the specific UEV partner. UBC14 (UBE2E1) is an E2 with a UBC catalytic domain and multiple splice isoforms; it participates in ubiquitin transfer reactions implicated in nuclear protein regulation, including histone H2A Lys119 monoubiquitination with PRC1-related activity, and shows regulated nucleo-cytoplasmic distribution linked to control of ubiquitination-dependent stability of key signaling proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: At5g59300; AtUBC13; AtUBC13A; AtUBC13B; AtUBC14; AtUBC7; E2 ubiquitin-conjugating enzyme 14; MNC17.21; TaUBC7; TAYO29; UBC7_ARATH; UbcAt3; Ubiquitin carrier protein 14; Ubiquitin-protein ligase 14
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