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Invitrogen
UBE2B Recombinant Rabbit Monoclonal Antibody (2Z3R2)
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UBE2B Antibody (MA5-42600) in IHC (P)
Immunohistochemistry analysis of UBE2B in paraffin-embedded human esophageal cancer. Samples were incubated with UBE2B Monoclonal antibody (Product # MA5-42600) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-42600
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2Z3R2
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.33 mg/mL
规格
33 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HeLa, 293T, NIH/3T3, K-562, Mouse testis, Mouse heart, Rat testis. The target is usually found in the following locations: Cell membrane, Nucleus.
Immunogen sequence: FKLVIEFSEE YPNKPPTVRF LSKMFHPNVY ADGSICLDIL QNRWSPTYDV SSILTSIQSL LDEPNPNSPA NSQAAQLYQE NKREYEKRVS AIVEQSWNDS
靶标信息
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2 protein; E2 ubiquitin-conjugating enzyme B; E2(14k); HHR6B (Human homologue of yeast RAD 6); putative; RAD6 homolog B; UBE2B; ubiquitin carrier protein B; ubiquitin conjugating enzyme; ubiquitin conjugating enzyme E2B; ubiquitin-conjugating enzyme E2(14k); ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homolog; ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-protein ligase B; unnamed protein product
基因别名: E2-14k; E2-17kDa; E214K; HHR6B; HR6B; mHR6B; RAD6B; UBC2
UniProt ID: (Human) P63146, (Mouse) P63147, (Rat) P63149
Entrez Gene ID: (Human) 7320, (Mouse) 22210, (Rat) 81816
protein polyubiquitination
in utero embryonic development
DNA repair
postreplication repair
chromatin organization
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
spermatogenesis
sperm axoneme assembly
response to xenobiotic stimulus
response to UV
positive regulation of reciprocal meiotic recombination
protein ubiquitination
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
meiotic telomere clustering
protein stabilization
chiasma assembly
protein autoubiquitination
synaptonemal complex organization
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
positive regulation of canonical Wnt signaling pathway
negative regulation of post-translational protein modification
response to hypoxia
cellular response to insulin stimulus
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