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Invitrogen
UBE2C Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-117019
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human UBE2C (NP_0089501)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.79 mg/mL
规格
179 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 22Rv1, THP-1, U-87MG, SW620, SKOV3
Immunogen sequence: MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP
靶标信息
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; RP3-447F3.1; UbcH10; Ubiquitin carrier protein C; Ubiquitin-conjugating enzyme E2 C; Ubiquitin-protein ligase C
基因别名: 1110015A16Rik; D2Ertd695e; UBCH10; UBE2C
UniProt ID: (Mouse) Q9D1C1
Entrez Gene ID: (Rat) 296368, (Mouse) 68612
protein polyubiquitination
ubiquitin-dependent protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
exit from mitosis
free ubiquitin chain polymerization
protein ubiquitination
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
positive regulation of exit from mitosis
protein K48-linked ubiquitination
protein K11-linked ubiquitination
cell cycle
mitotic nuclear division
cell division
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